Ankylosing spondylitis is a form of chronic inflammation of the spine and the sacroiliac joints. The sacroiliac joints are located at the base of the low back where the sacrum (the bone directly above the tailbone) meets the iliac bones (bones on either side of the upper buttocks) of the pelvis. Chronic inflammation in these areas causes pain and stiffness in and around the spine, including the neck, middle back, lower back, and buttocks. Over time, chronic inflammation of the spine (spondylitis) can lead to a complete cementing together (fusion) of the vertebrae, a process referred to as ankylosis. Ankylosis causes loss of mobility of the spine. There's no cure for ankylosing spondylitis (AS) often referred as Bechterew's disease is also called Marie Strumpell disease, rheumatoid. The presence of symptoms other than back pain depends on the disease stage. Spondyloarthropathies (SpAs), is one of the most common inflammatory rheumatic diseases like rheumatoid arthritis (RA), AS Stages: Stage I Grade II or higher bilateral radiographic sacroiliitis, Stage II Minor radiographic evidence of spinal involvement in ?1 spinal Segment (?3 vertebrae which equals 15% of the spine), Stage III Moderate radiographic evidence of spinal involvement in ?2 spinal segments (4–12 vertebrae which equals 15– 50% of the spine), Stage IV Radiographic evidence of spinal involvement in 2 spinal segments (13–19 vertebrae which equals 50– 80% of the spine), Stage V Widespread (?80%) fusion of the spine (?20 vertebrae). Best Served Cold The length of time from when you start using ASR until you see results varies with each person. While some people see changes as soon as 30 days, it may take others longer or sooner to see a difference. Recommended dose size: 15 ml or 1 tablespoon (after breakfast) and 15 ml (after lunch). Open bottle to be refrigerated. Servings per bottle: 4. To experience the difference Pack of 3 is highly recommended. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.