As host of American Bandstand, Clark introduced rock & roll to many Americans. The show gave many new music artists their first exposure to national audiences, including Iggy Pop, Ike & Tina Turner, Smokey Robinson and the Miracles, Stevie Wonder, Prince, Talking Heads, Simon & Garfunkel and Madonna. Episodes he hosted were among the first in which blacks and whites performed on the same stage, and likewise among the first in which the live studio audience sat without racial segregation. Singer Paul Anka claimed that Bandstand was responsible for creating a "youth culture". Due to his perennially youthful appearance and his largely teenaged audience of American Bandstand, Clark was often referred to as "America's oldest teenager" or "the world's oldest teenager".

In his off-stage roles, Clark served as Chief Executive Officer of Dick Clark Productions (a financial interest in which he sold off in his later years). He also founded the American Bandstand Diner, a restaurant chain modeled after the Hard Rock Cafe. In 1973, he created and produced the annual American Music Awards show, similar to the Grammy Awards.

Clark suffered a stroke in December 2004. With speech ability impaired, Clark returned to his New Year's Rockin' Eve show a year later on December 31, 2005. Subsequently, he appeared at the 58th Primetime Emmy Awards in 2006, and every New Year's Rockin' Eve show through the December 31, 2011 episode. He died on April 18, 2012, of a heart attack, at the age of 82, following prostate surgery.