Sisters is an American family drama television series which aired on NBC for six seasons from May 11, 1991 to May 4, 1996. The series was created by Ron Cowen and Daniel Lipman, who were also the executive producers and showrunners. The show debuted on May 11, 1991 for a seven-episode test run and was subsequently renewed for the 1991 fall schedule.

Sisters focused on four very different sisters living in Winnetka, Illinois. Their recently deceased father, Thomas Reed, a doctor, had been absent and a workaholic, while their long-suffering mother, Beatrice, turned to alcoholism to cope with his neglect and affairs. Having always wanted sons, their father had called the girls by male versions of their full names: Alexandra was called Alex; Theodora, Teddy; Georgiana, Georgie; and Francesca, Frankie.

For the first two seasons, each episode began with the sisters' weekly ritual of chatting in a steam bath together, but switched to a more traditional opening sequence beginning with the 1992–1993 season: glossy, black-and-white filmed scenes of the sisters engaging in various activities during both their childhood and adult years. Initially, the only soundtrack used for the opening was the sounds of the characters, but in the fall of 1993 a piano solo composed by John Debney was added as theme music.

Most episodes of the show featured a number of flashbacks, in which the characters would interact with or simply observe their younger selves (played by younger actresses). Although the show was a drama with soap opera–style storylines, the show was also quirky and offbeat in the style of other shows at the time like CBS's Northern Exposure.