The Asus M5A97 EVO R2.0 uses the AMD Socket AM3+ CPU socket. Any compatible AMD CPU will have the same socket entry. It uses the DDR3 memory type, with maximum speeds of up to 2133 MHz, and 4 DDR3 slots allowing for a maximum total of 32 GB RAM. 

Conforming to the ATX standard, the Asus M5A97 EVO R2.0 should fit into the majority of cases. ATX is the most common form factor, and as such has a high degree of compatibility with other components while providing a decent number of slots to widen your expansion options. 

The Asus M5A97 EVO R2.0 has 6 SATA 3.0 hard drive slots. These allow for theoretical data transfer speeds of up to 6GB/s, as opposed to the 3GB/s of SATA 2.0. Generally speaking, only high performance hard drives, specifically solid-state drives, will be able to take advantage of the bandwidth potential of SATA 3.0 ports, though it is backwards compatible, so you do not have to take advantage. 

The Asus M5A97 EVO R2.0 does not support onboard graphics. Any system build that uses this motherboard therefore requires a separate graphics card, or a processor that has a GPU on the same die, such as AMD APU processors. There are 1 PCIe x16 slots on this motherboard. This means it is perfectly capable of accommodating the latest graphics cards, although it is important to try and use a graphics card with the same graphics card interface of PCIe v2.x, as anything below will not reach the motherboard's potential, and anything above will have its performance slashed to the bandwidth maximum of the Asus M5A97 EVO R2.0's PCIe v2.x. The Asus M5A97 EVO R2.0 supports up to 2 Nvidia SLI connected graphics cards or up to 2 AMD Crossfire connected graphics cards for improved overall graphical performance at the cost of multiplied graphics-based power consumption as well as the price of the cards themselves. 

The Asus M5A97 EVO R2.0 has 10 USB 2.0 slots and 4 USB 3.0 slots. USB 3.0 slots are theoretically capable of data transfer speeds of up to 5 Gbit/s, which is over 10 times faster than the USB 2.0 top speed of 480 Mbit/s. Although USB 2.0 slots alone currently serve as well as ever, an upgrade would better future-proof your system as more USB 3.0 compatible peripherals emerge. USB 3.0 is also backwards compatible with USB 2.0, which means you do not even have to use the newer slot functionality if you do not wish to.