Traditional vampires Nandor, Laszlo, and Nadja, together with energy vampire Colin Robinson, share a Staten lsland residence, maintained by Nandor's familiar Guillermo. The vampires routinely clash with the modern world, other supernatural beings, and/or each other, while Guillermo earnestly endeavors to balance his loyalty to Nandor with his desire to become a vampire, complicated by his ancestry as a descendant of vampire hunter Van Helsing.