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Pharmacotherapeutic group: metabolic agent.
Dosage form: sublingual tablets.
Description: round flat-cylindrical tablets of white or almost white color with elements of marbling with bevelling and scoring.
pharmachologic effect

Pharmacodynamics
Glycine is an amino acid and one of the main inhibitory neurotransmitters in the brain. Glycine normalizes and activates the processes of protective inhibition in the central nervous system, reduces psycho-emotional stress, and increases mental performance.
Glycine has glycine and GABAergic, alpha1-adrenergic blocking effects, regulates the activity of glutamate (NMDA) receptors.
The drug has the following properties:
- reduces psycho-emotional stress, aggressiveness, conflict, increases social adaptation;
- improves mood;
- facilitates falling asleep and normalizes sleep;
- increases mental performance;
- reduces vegetative-vascular disorders (including in menopause);
- reduces the severity of cerebral disorders in ischemic stroke and traumatic brain injury;
- reduces the toxic effect of alcohol and other drugs that inhibit the function of the central nervous system.

Pharmacokinetics
Easily penetrates into most biological fluids and body tissues, incl. into the brain; metabolized to water and carbon dioxide; accumulation in the body does not occur.
Indications

- Reduced mental performance;
- stressful situations - psychoemotional stress (during exams, in conflict situations, etc.);
- deviant (deviating from the norm) forms of behavior of children and adolescents;
- various functional and organic diseases of the nervous system, accompanied by increased excitability, emotional instability, decreased mental performance, memory and sleep disorders: neuroses, neurosis-like states and vegetative-vascular dystonia, stress nervous disorders, the consequences of neuroinfections and traumatic brain injury, perinatal and others forms of encephalopathy (including alcoholic genesis);
- ischemic stroke.
Method of administration and dosage

Glycine is used sublingually or buccal (in tablets or in powder form after crushing a tablet): adults, adolescents and children over three years old - 1 tablet (100 mg), children under three years old - 0.5 tablets (50 mg).
Glycine is prescribed to practically healthy children, adolescents and adults with psycho-emotional stress, stressful nervous disorders, memory loss, attention, mental performance, mental retardation, with deviant behaviors: 2-3 times a day for 14-30 days.
With functional and organic lesions of the nervous system, accompanied by increased excitability, emotional lability and sleep disturbance:
- children under three years old: 2-3 times a day for 7-14 days, then 1 time a day for 7-10 days, daily dose - 100-150 mg, course dose - 2000-2600 mg;
- children over three years old, adolescents and adults: 2-3 times a day for 7-14 days, daily dose - 200-300 mg, course dose - 2800-4200 mg;
On the recommendation of a doctor, the course of treatment can be increased to 30 days, if necessary, the course is repeated after 30 days.
For sleep disorders: 20 minutes before bedtime or immediately before bedtime, 0.5-1 tablet (depending on age).
With ischemic cerebral stroke: during the first 3-6 hours from the development of a stroke, 1000 mg is prescribed sublingually or buccal with one teaspoon of water, then for 1-5 days, 1000 mg per day, then 1-2 tablets for the next 30 days 3 times a day.
In narcology, glycine is used as an agent that increases mental performance and reduces psycho-emotional stress during remission with symptoms of encephalopathy, organic lesions of the central and peripheral nervous system: 1 tablet 2-3 times a day for 14-30 days. If necessary, courses are repeated 4-6 times a year.
Side effects

Allergic reactions (very rare).
Contraindications

Hypersensitivity to glycine or to other components of the drug.

Application during pregnancy and during breastfeeding
Glycine is not recommended during pregnancy and breastfeeding due to the lack of sufficient data.
Overdose

No cases of overdose have been identified.
special instructions

In patients with a tendency to arterial hypotension (BP), the drug is used under the control of blood pressure and, if necessary, the dose is adjusted (reduced). With a decrease in blood pressure below the usual level, the reception is discontinued.
Possibility of the drug's influence on the ability to drive vehicles and other potentially dangerous mechanisms: does not.
Precautions for use: does not require special precautions.
Interaction with other drugs

Reduces the severity of side effects of antipsychotics (neuroleptics), anxiolytics, antidepressants, hypnotics and anticonvulsants

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Structure

Composition for one tablet: microencapsulated glycine (in terms of the active ingredient glycine - 100 mg), excipients: methylcellulose - 1 mg, magnesium stearate - 1 mg.
Storage conditions

Store at a temperature not exceeding +25 ? in original packaging.
Keep out of the reach of children.

Expiration date: 3 years.
Do not use later than the date indicated on the package.