One gremlin drank some brain hormones and began super intelligent...his name is Brain.  The Brain Gremlin (or just simply Brain) is the main antangonist in Gremlins 2 The New Batch.  He is one of the gremlins that invaded the Clamp Center building. He is a brown mutated gremlin who wears glasses and later on more formal clothing. He has a well-spoken human voice which he got after consuming a beaker full of mutagenetic brain hormone serum in the Clamp Center laboratory and his intelligence was greatly increased as a result as well. Afterwards, he dressed more like that of a human, wearing very business-like clothing and even gaining spectacles that had appeared from no known location or source. Although he is a villain, for a gremlin, he is well articulated and cultured, though his mischievous nature still prevails. He does not appear to be as destructive as the other gremlins and appears to be somewhat fascinated by the humans' culture and way of life.  The Brain Gremlin was voiced by the late actor Tony Randall.

Gremlins is a 1984 American black comedy horror film directed by Joe Dante and written by Chris Columbus, and starring Zach Galligan, Phoebe Cates, Hoyt Axton, Polly Holliday and Frances Lee McCain, with Howie Mandel providing the voice of Gizmo, the main mogwai character. It draws on legends of folkloric mischievous creatures that cause malfunctions—"gremlins"—in the British Royal Air Force going back to World War II. The story follows a young man who receives a strange creature as a pet, which then spawns other creatures who transform into small, destructive, aggressive monsters that all wreak havoc on a whole town on Christmas Eve.

It was followed by a sequel, Gremlins 2: The New Batch, in 1990, which has a more satirical tone and parodies Hollywood sequels, to generally positive reviews from critics.

A third film, Gremlins 3, is in active development as of 2022.

In a December 2016 interview with Bleeding Cool, Galligan again spoke about a third film saying that "Warner Bros. definitely wants it, Chris Columbus wants to do it because he’d like to undo the Gremlins 2 thing as he wasn’t thrilled with it, and Spielberg wants to." He claimed Gremlins 3 is being written by Carl Ellsworth. In an interview with Film in 2017, a script was written by Chris Columbus. His script explored the idea that has been on the fan's mind for a long time: "if all the gremlins come from getting Gizmo wet and feeding his mogwai offspring after midnight, should Gizmo be eliminated?" He described his script as "twisted and dark".

In 2019, Warner Bros. successfully gained registered trademark of the name and the franchise. That same year, the studio's parent company WarnerMedia greenlit an animated series, Gremlins: Secrets of the Mogwai based on the property for its streaming service, HBO Max.

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