The baseball game between the Chicago Cubs and the Philadelphia Phillies on August 18, 1991, is notable for being the first game in MLB history to start with the first three batters of a team hitting home runs. Phillies' leadoff hitter Lenny Dykstra, followed by Mickey Morandini and John Kruk, all hit home runs off Cubs' pitcher Mike Harkey at the start of the game. This rare occurrence marked a significant moment in MLB history.