Harrison Ford .... Dr. Richard Kimble
Tommy Lee Jones .... Samuel Gerard
Sela Ward .... Helen Kimble
Julianne Moore .... Dr. Anne Eastman
Joe Pantoliano .... Cosmo Renfro
Andreas Katsulas .... Sykes
Jeroen Krabbé .... Dr. Charles Nichols (as Jeroen Krabbe)
Daniel Roebuck .... Biggs
L. Scott Caldwell .... Poole
Tom Wood .... Newman
Ron Dean .... Det. Kelly
Joseph F. Kosala .... Det. Rosetti (as Joseph Kosala)
Miguel Nino .... Chicago cop #1
John Drummond .... Newscaster
Tony Fosco .... Chicago cop #2
Joseph F. Fisher .... Otto Sloan
James Liautuad .... Paul
David Darlow .... Dr. Lentz
Tom Galouzis .... Surgeon (as Tom Galouzis M.D.)
James F. McKinsey .... Surgeon (as James F. McKinsey M.D.)
Mark D. Espinoza .... Resident
John E. Ellis .... Anesthesiologist
Gene Barge .... 11th District cop
Thomas Charles Simmons .... 11th District cop (as Thomas C. Simmons)
Joe Guzaldo .... Prosecutor (as Joseph Guzaldo)
Dick Cusack .... Walter Gutherie
Nicholas Kusenko .... Assistant defense attorney (as Nick Kusenko)
Joan Kohn .... Assistant prosecuting attorney
Joe D. Lauck .... Forensic technician
Joe Guastaferro .... Coroner (as Joseph V. Guastaferro)
Andy Romano .... Judge Bennett
Richard Riehle .... Old guard
Thom Vernon .... Carlson
Ken Moreno .... Partida
Eddie Bo Smith Jr. .... Copeland (as Eddie 'Bo' Smith Jr.)
Frank Ray Perilli .... Jail officer
Otis Wilson .... Jail officer
Pancho Demmings .... Young guard
Jim Wilkey .... Bus driver
Danny Goldring .... Head Illinois state trooper
Nick Searcy .... Sheriff Rawlins
Kevin Crowley .... State trooper
Michael James .... Head welder
Michael Skewes .... Highway Patrolman
Ila Cathleen Stallings .... Duty nurse
Linda Casaletto .... Rural hospital nurse
Cody Glenn .... Paramedic
Cynthia Baker .... Woman in car
Johnny Lee Davenport .... Marshal Henry
Mike Bacarella .... Marshal Stevens
Bill Cusack .... Tracing technician
David U. Hodges .... Marshal David (as David Hodges)
Lillie Richardson .... Copeland's girlfriend
Peter J. Caria IV .... Billy
Tighe Barry .... Windshield washer
Monika Chabrowski .... Polish landlady
Lonnie Sima .... Landlady's son
Oksana Fedunyszyn .... Myoelectric receptionist
Orlando García .... Desmondo
Afram Bill Williams .... Salesman
Bruce L. Gewertz .... Dr. Bruce (as Bruce L. Gewertz M.D.)
Jane Lynch .... Dr. Kathy Wahlund
Joseph Rotkvich .... Officer Joseph
Steven Lilovich .... Officer Steve
Noelle Bou-Sliman .... Myoelectric technician
Roxanne Roberts .... Trauma doctor
Alex P. Hernandez .... Trauma doctor (as Alex Hernandez)
Theron Touché Lykes .... Orderly (as Theron Touche Lykes)
Joel Robinson .... Boy patient
Greg Hollimon .... Skating orderly
Cheryl Lynn Bruce .... O/R doctor
Marie Ware .... Nurse Gladys
Bernard McGee .... Man
Ann Whitney .... Myoelectric director
Lily Monkus .... Desk clerk
Willie Lucas .... Desk clerk
Turk Muller .... Clearing officer
Ana María Alvarez .... La Cubana
Eugene F. Crededio .... Visitation guard
Maurice Person .... Clive Driscoll
Terry Hard .... Officer Hormel
Pam Zekman .... Newscaster
David Pasquesi .... Newscaster
Brent Shaphren .... Doctor at bar
Stephen A. Landsman .... Doctor at bar
B.J. Jones .... Doctor at bar
Dru Anne Carlson .... Gerard's secretary (as Drucilla A. Carlson)
Margaret Moore .... Nichols' assistant
Manny Lopez .... Seminar doctor
John M. Watson Sr. .... Bones Roosevelt
Kirsten Nelson .... Betty
Juan Ramírez .... Man on 'El' (as Juan A. Ramírez)
Neil Flynn .... Transit cop
Allen Hamilton .... Host
Eric Fudala .... Hotel security guard
Lester Holt .... Newscaster
Jay Levine .... Newscaster
Beth A. Landsman .... Wife of doctor at bar (uncredited)
Jack Rooney .... Extra (uncredited)
Keith Schrader .... Hotel Security Guard (uncredited)
John-Clay Scott .... Mad motorist at tunnel (uncredited)

Wrongly convicted of murdering his wife, Dr. Richard Kimble escapes from a prison bus and tries to find out why she was killed and who the murderer really was. He is relentlessly pursued by Samuel Gerard, a U.S. Marshal, and is forced to keep out of contact from any friends or relatives. However, his determination and ingenuity soon produce results and he comes to the frightening realisation that he can trust no one.

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