Michael Keaton .... Billy Caufield
Christopher Lloyd .... Henry Sikorsky
Peter Boyle .... Jack McDermott
Stephen Furst .... Albert Ianuzzi
Dennis Boutsikaris .... Dr. Weitzman
Lorraine Bracco .... Riley
Milo O'Shea .... Dr. Newald
Philip Bosco .... O'Malley
James Remar .... Gianelli
Jack Gilpin .... Dr. Talmer
MacIntyre Dixon .... Dr. Verboven
Michael Lembeck .... Ed
Bill Goffi .... Singer/Accordionist
Jack Duffy .... Bernie
Brad Sullivan .... Sergeant Vincente
Larry Pine .... Canning
Harold Surratt .... Pastor Lester
Kenneth Raybourne .... Gospel Musician
Alphonsus E. Platt .... Gospel Musician
Robert Weil .... Caesar
Janet Feindel .... Senior Nurse
Tico Wells .... Station Attendant
Barry Flatman .... Arrogant Yuppie
Ted Simonett .... Yuppie
Bruce Hunter .... Yuppie
John Stocker .... Murray
Lizbeth MacKay .... Henry's Wife
Olivia Horton .... Henry's Daughter
Richard Fitzpatrick .... Dr. Bauer
Jack Jessop .... Dr. Meekum
Ron James .... Dwight
Dennis Parlato .... TV Newscaster
Freda Foh Shen .... TV Newscaster
Donna Hanover .... Field Reporter
Greg Beresford .... Field Reporter
Eric Fink .... Priest
Wayne Tippit .... Captain Lewitt
A. Frank Ruffo .... Relative
Michael Copeman .... Con Ed Man
Victor Ertmanis .... Man in Mets Jersey
Cynthia Belliveau .... Nurse
Stewart Bick .... Paramedic
James O'Regan .... Litterbug
Dick Callahan .... Bartender
Shelley Goldstein .... Waitress
Jihmi Kennedy .... Tow Man
Marty Waldman .... Salesman
Michelyn Emelle .... Duty Nurse Harriet
Michael Beatty .... Intern
Jane Luk .... Admissions Nurse
Marilyn Peppiatt .... Floor Nurse
Myra Fried .... Floor Nurse
J.R. Zimmerman .... Hospital Guard
Maxine Miller .... Newald's Secretary
Pat Idelette .... Woman at Police Station
Max Haines .... Guard
Henry Gomez .... Guard
Ellen Maguire .... Diana
Al Therrien .... Security Guard
Don Saunders .... Security Guard
John Liddle .... Cop
Dwayne McLean .... Old Gent
Kay Hawtrey .... Nurse
Patricia Carroll Brown .... Nurse (as Patricia Carol Brown)
Chick Roberts .... Old Guard
Nicholas Pasco .... Man Out Window
John Hayden .... Cop (uncredited)
Roger Montgomery .... Church Bouncer (1989) (uncredited)

Dr. Weitzman works with patients in a sanitarium. Convinced that all that his "group" needs is a some fresh air and some time away from the sanitarium, he pursuades the administration to allow him to take them to a ballgame. Unfortunately, he accidentally stumbles across a crime in progress and ends up in hospital. The group are stranded in New York City, forced to cope with a place which is often more bizarre than their sanitarium.

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