Semifinals
March 25
Michigan State (5) 78, Duke (1) 68
The Spartans of Michigan State continued on to the Regional Finals by outplaying Duke in the second half and breaking a 32–32 halftime tie. Michigan State came out in the second half and secured the momentum in slowly, but surely, pulling away from Duke. The Spartans got out to a nine-point lead, allowed Duke to get within two, but then, scoring their last ten points of the game on free throws, moved on to the Regional Finals.
Kentucky (2) 62, Utah (6) 52
After playing Kentucky well in the first half, only trailing by five at halftime, Utah ran out of steam. Utah's last chance to win the game came after Andrew Bogut missed a free throw with Utah down 38–35 with 12:17 to play. Kentucky gradually pulled away to meet Michigan State in the Regional Finals.
Final
March 27
Michigan State (5) 94, Kentucky (2) 88 (2 OT)
In this double-overtime thriller, Kentucky started out well and led Michigan State by four at halftime, but Michigan State caught up in the second half, actually leading 70–62 with 5:43 to play. Kentucky rallied back, however, cutting the lead to one when Kelenna Azubuike drained a three with 1:19 to play. After Patrick Sparks missed the front end of a one-and-one with 41 seconds to play, Michigan State's Shannon Brown appeared to ice the game with two free throws with 20 seconds to play. But with time expiring, Sparks put up a prayer from three, and the ball bounced around the rim four times before falling in. After the referees spent nearly ten minutes reviewing the play, they upheld that Sparks' shot was a three pointer, sending the game into overtime. In the first overtime, neither team relented, and Brown hit a key three-point basket for Michigan State to keep them in the game. Kentucky's Azubuike missed a three as time expired to send the game into double overtime. In the second overtime, Michigan State's mettle finally won the game for them, as they scored 11 of their 13 points from the free throw line to finally seal the game and send them to the Final Four for the fourth time under coach Tom Izzo.