Charles Grodin .... George Newton
Bonnie Hunt .... Alice Newton
Dean Jones .... Herman Varnick, D.V.M.
Nicholle Tom .... Ryce Newton
Christopher Castile .... Ted Newton
Sarah Rose Karr .... Emily Newton
Oliver Platt .... Harvey
Stanley Tucci .... Vernon
David Duchovny .... Brad
Patricia Heaton .... Brie
Robi Davidson .... Mark
Laurel Cronin .... Devonia Pest
O-Lan Jones .... Biker Woman
Nancy Fish .... Miss Grundel
Craig Pinkard .... Homeless Man
Sherri Paysinger .... Ruth Walters (the Reporter)
Patrick LaBrecque .... Bully #1
Jacob Kenner .... Bully #2
Matthew Brooks .... Bully #3
Chris Little .... Newsreader
Lisa Gerber .... Donna Dittsworth
Cory Danziger .... Mark's Friend
Colleen O'Hara .... Young Woman
Stephanie Massman .... Young Woman
Nicolas Mize .... Young Man
Maxine Elliott Hicks .... Old Woman (as Maxine Elliott)
Cirroc Lofton .... Skateboarder #1
Chad Morton .... Skateboarder #2
Melora Walters .... Pet Shop Owner
Holly Wortell .... Nurse #2
Lorraine Marga .... Mother at Pet Store
Joseph Gordon-Levitt .... Student
Andres McKenzie .... Student #2

The Newton family live in their comfortable home, but there seems to something missing. This "hole" is filled by a small puppy, who walks into their home and their lives. Beethoven, as he is named, grows into a giant of a dog... a St Bernard. Doctor Varnick, the local vet has a secret and horrible sideline, which requires lots of dogs for experiments. Beethoven is on the bad doctor's list.

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