Cary Grant ... Dr. Barnaby Fulton
Ginger Rogers ... Mrs. Edwina Fulton
Charles Coburn ... Mr. Oliver Oxley
Marilyn Monroe ... Miss Lois Laurel
Hugh Marlowe ... Hank Entwhistle
Henri Letondal ... Dr. Jerome Kitzel
Robert Cornthwaite ... Dr. Zoldeck
Larry Keating ... G.J. Culverly
Douglas Spencer ... Dr. Brunner
Esther Dale ... Mrs. Rhinelander
George Winslow ... Little Indian
Charlotte Austin ... Student (uncredited)
Harry Bartell ... Scientist (uncredited)
Faire Binney ... Dowager (uncredited)
Harry Carey Jr. ... Reporter (uncredited)
Olive Carey ... Johnny's Mother (uncredited)
Harry Carter ... Scientist (uncredited)
Ronnie Clark ... Boy (uncredited)
Russ Clark ... Policeman (uncredited)
Heinie Conklin ... House Painter (uncredited)
George Eldredge ... Mr. Peabody (uncredited)
Kathleen Freeman ... Mrs. Brannigan, Neighbor (uncredited)
Terry Goodman ... Boy (uncredited)
Dabbs Greer ... CabBIE (uncredited)
Howard Hawks ... Man In OpeninG (voice) (uncredited)
Marjorie Holliday ... Oxley Receptionist (uncredited)
Rudy Lee ... Boy (uncredited)
Louis Lettieri ... Boy (uncredited)
Mickey Little ... Boy (uncredited)
Emmett Lynn ... Gus (uncredited)
Paul Maxey ... Board Member (uncredited)
John McKee ... Photographer (uncredited)
Bill McLean ... Bellboy (uncredited)
Joseph Mell ... Barber (uncredited)
Christopher Milne ... Johnny (uncredited)
Jonathan Milne ... Johnny (uncredited)
Nico Minardos ... Handsome Guy at Pool (uncredited)
Ray Montgomery ... Policeman (uncredited)
Roger Moore ... Bit (uncredited)
Brad Morrow ... Boy (uncredited)
Forbes Murray ... Board Member (uncredited)
Robert Nichols ... Garage Man (uncredited)
Jerry Paris ... Scientist (uncredited)
Melinda Plowman ... Girl (uncredited)
Maudie Prickett ... Clerk (uncredited)
Jimmy Roebuck ... Boy (uncredited)
Harry Seymour ... Clothing Store Salesman (uncredited)
Jerry Sheldon ... Joe (uncredited)
Olan Soule ... Pickwick Arms Clerk (uncredited)
Gil Stratton ... Yale Man (uncredited)
Ruth Warren ... Laundress (uncredited)
Mack Williams ... Board Member (uncredited)
Isabel Withers ... Laundress (uncredited)

Barnaby Fulton is a research chemist working on a fountain of youth pill for a chemical company. While trying a sample dose on himself, he accidentally gets a dose of a mixture added to the water cooler and believes his potion is what is working. The mixture temporarily causes him to feel and act like a teenager, including correcting his vision. When his wife gets a dose that is even larger, she regresses even further into her childhood. When an old boyfriend meets her in this state, he believes that her never wanting to see him again means a divorce and a chance for him

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